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thorum 20 hours ago [-]
Somewhat useless article. To summarize, we have anecdotes suggesting they may work but no one has figured out how to prove or disprove it in a study, and the author has some doubts. Meanwhile supplements can be dangerous if you take too much or have a liver condition, or if you buy them from an unreputable source, as with every other substance on earth. Author confirms it tastes good in milk.
mgh2 20 hours ago [-]
Not useless if it pinpointed that most of the foundational research papers that initiated this trend were of dubious intellectual integrity- i.e. the source was compromised
9 hours ago [-]
notaharvardmba 20 hours ago [-]
The mind-body connection is also real.
collyw 21 hours ago [-]
I has tennis elbow a while ago. Was going to see the doctor but there was a wait. Looked up natural antiinflamatories. Turmeric came up. Did turmeric and black pepper milkshakes for a week and it fixed it.
amanaplanacanal 21 hours ago [-]
I hear you. The problem is... It might have just gotten better by itself. Hard to know.
collyw 5 hours ago [-]
Maybe.
wappieslurkz 6 hours ago [-]
One problem is: a tennis elbow does not really involve inflammation... Look it up.
collyw 5 hours ago [-]
I did, it says it sometimes involves inflammation, but it was self diagnosed anyway.Either way I drank turmeric milkshakes and it went away. Maybe by itself, maybe because of the turmeric.
wappieslurkz 1 hours ago [-]
Good thing it did, I've been struggling with it for 9 months now. I'm seeing a new specialist next week.
Noumenon72 20 hours ago [-]
How long had the problem persisted before you considered going to the doctor?
collyw 5 hours ago [-]
Probably a bit over a week. Twinged after kayaking at the weekend. Got worse the following weekend and wasn't going away.
Daishiman 21 hours ago [-]
Or the turmeric did nothing and it fixed itself the way the vast majority of injuries heal.
DANmode 20 hours ago [-]
Turmeric always does something.
Whether it’s enough to make a difference in your case depends.
jml7c5 19 hours ago [-]
The problem is that this is either unsupported by evidence or a meaninglessly shallow claim. After all, almost every herbal remedy does something, but it doesn't mean it's actually therapeutic for some given condition.
DANmode 19 hours ago [-]
The problem is, you’re out of date regarding the recent efforts put into studying and documenting long-known herbs.
Curcumin is a polyphenol that operates at the molecular level to disrupt multiple inflammatory cascades. It achieves this by simultaneously blocking the transcription of inflammatory genes and interrupting the enzymes responsible for generating pain and swelling.
I’ve got a couple other examples I’ve come across recently that I can additionally share.
atombender 18 hours ago [-]
That paper is co-authored by Bharat B. Aggarwal, who has been found to produce fraudulent research [1], and many of whose papers have been retracted. This is the guy mentioned in the New Scientist article!
Curcumin has been extensively studied, and a common observation is that it is fantastically bioactive in vitro, but tends to have zero meaningful properties when introduced into the biology of a real human being. Researchers have categorized it as an IMPS (invalid metabolic panacea), i.e. a drug whose chemical properties are an illusion, and has ended up becoming a "black hole" for scientific funding [2] [3].
The part about how it "disrupts multiple inflammatory cascades" and so on sounds terrific until you realize these are behaviours observed in vitro. The fact is that curcumin is unstable and highly reactive, so it gets torn apart and neutralized early during digestion, leading to insanely low bioavailability. Tons of compounds are anti-inflammatory in vitro. Very few actually are in the human body.
Also curious how many of those detracting have observed the use of capsules,
or the difference in a person not making proper gut acids / liver function.
frogcommander 5 hours ago [-]
[dead]
anon291 20 hours ago [-]
If turmeric had health benefits, we would expect India to be the world leader in that particular benefit. There are so few areas in which India is a leader that the answer is obviously no.
Like I get that turmeric is exotic and that a lot of non-Indians take turmeric pills and supplements, but Indian food has tons of turmeric as a normal ingredient. We would go through bottles and bags of the stuff like nothing. I don't understand these supplements and the treatment of turmeric as a medicine. Some supplements even tell you to talk to your doctor before eating turmeric! That's crazy. What next, talk to your therapist before taking garlic?
blargey 18 hours ago [-]
Culinary turmeric is about ~3% curcuminoids by weight (and only 60-70% of that is curcumin specifically). Curcumin also has low oral bioavailability, typically offset by taking a large dose (1000mg) and combining with piperine - even ignoring the piperine, that 1g of curcumin amounts of 66g of turmeric.
The average Indian household does not use 60g of turmeric per person per day. More like 1.5-2g per person per day, or ~30mg of curcumin, and without much to improve absorption.
Curcumin can, in fact, interact with anticoagulants and affect iron absorption at high supplemental doses, which is not a concern at culinary amounts.
There are reasons to be skeptical of the clinical evidence for curcumin supplementation, but "the heterogenous population of India isn't experiencing widespread miracle cures from culinary turmeric" is not one of them.
(And yes, garlic extract is also a thing, also extremely concentrated compared to eating whole garlics or seasoning with garlic powder, and has antiplatelet/anticoagulant activity that one should be aware of before taking such supplements)
Whether it’s enough to make a difference in your case depends.
Curcumin is a polyphenol that operates at the molecular level to disrupt multiple inflammatory cascades. It achieves this by simultaneously blocking the transcription of inflammatory genes and interrupting the enzymes responsible for generating pain and swelling.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10111629/
I’ve got a couple other examples I’ve come across recently that I can additionally share.
Curcumin has been extensively studied, and a common observation is that it is fantastically bioactive in vitro, but tends to have zero meaningful properties when introduced into the biology of a real human being. Researchers have categorized it as an IMPS (invalid metabolic panacea), i.e. a drug whose chemical properties are an illusion, and has ended up becoming a "black hole" for scientific funding [2] [3].
The part about how it "disrupts multiple inflammatory cascades" and so on sounds terrific until you realize these are behaviours observed in vitro. The fact is that curcumin is unstable and highly reactive, so it gets torn apart and neutralized early during digestion, leading to insanely low bioavailability. Tons of compounds are anti-inflammatory in vitro. Very few actually are in the human body.
[1] https://reeserichardson.blog/2024/01/30/the-king-of-curcumin...
[2] https://pubmed.ncbi.nlm.nih.gov/26505758/
[3] https://pubmed.ncbi.nlm.nih.gov/28074653/
Fair point, though. Good news, lots of others:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9881416/#S9
https://lpi.oregonstate.edu/mic/dietary-factors/phytochemica...
Also curious how many of those detracting have observed the use of capsules,
or the difference in a person not making proper gut acids / liver function.
Like I get that turmeric is exotic and that a lot of non-Indians take turmeric pills and supplements, but Indian food has tons of turmeric as a normal ingredient. We would go through bottles and bags of the stuff like nothing. I don't understand these supplements and the treatment of turmeric as a medicine. Some supplements even tell you to talk to your doctor before eating turmeric! That's crazy. What next, talk to your therapist before taking garlic?
The average Indian household does not use 60g of turmeric per person per day. More like 1.5-2g per person per day, or ~30mg of curcumin, and without much to improve absorption.
Curcumin can, in fact, interact with anticoagulants and affect iron absorption at high supplemental doses, which is not a concern at culinary amounts.
There are reasons to be skeptical of the clinical evidence for curcumin supplementation, but "the heterogenous population of India isn't experiencing widespread miracle cures from culinary turmeric" is not one of them.
(And yes, garlic extract is also a thing, also extremely concentrated compared to eating whole garlics or seasoning with garlic powder, and has antiplatelet/anticoagulant activity that one should be aware of before taking such supplements)